Phagocyte Biology Laboratory

Dr. Bryan Heit, Western University

About Us

Welcome! You have reached the homepage of the laboratory of Dr. Bryan Heit. Our lab is part of the Department of Microbiology and Immunology at Western University, and we are members of the Center for Human Immunology, the lead centre for the CIHR Human Immunology Network.

Our interests surround the function of phagocytes – white blood cells which ingest (phagocytose) pathogens, particles, and dead cells. We focus on the cellular and molecular processes which control the function of these cells during the maintenance of homeostasis, during infection and during chronic inflammatory disease. Central to most of our studies is the study of efferoctyosis – the phagocytic removal of apoptotic (dying) cells, and how failures in this process lead to inflammation, autoimmunity and infection.

Lab News

Another New Paper, and a Second In-Press!

Two more papers involving members of the Heit lab are either out, or are coming out in the very near future.

The first paper is a collaborative study with the Dikeako’s lab, an applies super-resolution micropscopy to the imaging and analysis of HIV infection:

ARHR

Click for link to paper

Dirk BS, Heit B, Dikeakos JD. Visualizing Interactions Between HIV-1 Nef and
Host Cellular Proteins Using Ground-State Depletion Microscopy. AIDS Res Hum
Retroviruses. 2015 May 18. [Epub ahead of print] PubMed PMID: 26061722.

 

 

 

Our second publication, in collaboration with the Klip lab (Toronto) investigates the mechanisms of lipid-induced inflammation and suppression of insulin transport in diabetes. It is currently available as a pre-publication PDF.

Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP,
Heit B, Bilan PJ, Lee WL, Klip A. Palmitate-induced inflammatory pathways in
human adipose microvascular endothelial cells promotes monocyte adhesion and
impairs insulin transcytosis. Am J Physiol Endocrinol Metab. 2015 May
5. [Epub ahead of print]. PubMed PMID: 25944880.

New Paper Published!

Our second paper of 2015 is officially in press. The in-press version of the paper can be found here.

Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP,
Heit B, Bilan PJ, Lee WL, Klip A. Palmitate-induced inflammatory pathways in
human adipose microvascular endothelial cells promotes monocyte adhesion and
impairs insulin transcytosis. Am J Physiol Endocrinol Metab. 2015 May. PMIDĀ 25944880.

Meet the newest member of the Heit lab

Our newest lab member, Charles Yin, has going to be featured in the next edition of Current Affairs, Schulich School of Medicine and Dentistry’s training newsletter. You can get an early peak at his interview here.

Charles Yin, Image from Current Affairs

Congratulations Honours Students!

honours2015

Honours Presentations 2015

Our honours students, Melanie and Yadin, completed their honours program yesterday with oral presentations of their work. Look for their contributions in our labs upcoming publications.

 

 

 

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Upcoming Events

July 11-15, 2015
American Society for Virology Annual Conference Hosted here at the University of Western Ontario by our home department, the Department of Microbiology & Imunology


September 10, 2015
Fall Semester Begins! Undergraduate and graduate courses start on September 10


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