Welcome! You have reached the homepage of the laboratory of Dr. Bryan Heit. Our lab is part of the Department of Microbiology and Immunology at Western University, and we are members of the Center for Human Immunology, the lead centre for the CIHR Human Immunology Network.
Our interests surround the function of phagocytes – white blood cells which ingest (phagocytose) pathogens, particles, and dead cells. We focus on the cellular and molecular processes which control the function of these cells during the maintenance of homeostasis, during infection and during chronic inflammatory disease. Central to most of our studies is the study of efferoctyosis – the phagocytic removal of apoptotic (dying) cells, and how failures in this process lead to inflammation, autoimmunity and infection.
Our second paper of 2015 is officially in press. The in-press version of the paper can be found here.
Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP,
Heit B, Bilan PJ, Lee WL, Klip A. Palmitate-induced inflammatory pathways in
human adipose microvascular endothelial cells promotes monocyte adhesion and
impairs insulin transcytosis. Am J Physiol Endocrinol Metab. 2015 May. PMID 25944880.
Our newest lab member, Charles Yin, has going to be featured in the next edition of Current Affairs, Schulich School of Medicine and Dentistry’s training newsletter. You can get an early peak at his interview here.
Our honours students, Melanie and Yadin, completed their honours program yesterday with oral presentations of their work. Look for their contributions in our labs upcoming publications.